Either make Kuru less deadly, or make Prions harder to get.

[Grayshift]

Basically: Kuru was the problem, not spider eggs/gibbis/nanomachines.

Look at it this way: 5 units of most of the other poisons are usually enough to kill or at least severely debilitate people. This change brings all poisons to roughly the same deadliness.

I am also torn on the subject of nanites. I will consider this but won't promise anything.

It really isn't a matter of deadliness though. If I wanted deadly I'd load my pen up with a sarin/cyanide/sulfonal mix and skip wasting any telecrystals on dud poison bottles. I want that disease stylishness, I want people screaming about spiders and GBS over the radio, and I can hardly call eight people max per lucky poison bottle draw a proper epidemic. Especially when you have to put up with the solid chance of not getting any disease reagent at all.

Diseases are "frightening" but easy to cure if you keep your head. Kuru was the overpowered exception and I'm glad it got nerfed.

I just don't think I'll ever want to spend crystals on poison with this change. For me, the whole point of gambling on the poison bottle lottery was the chance to become Pestilence.

If I can't argue the threshold limit away for nanites/spider eggs/gibbis away entirely, some alternative suggestions...
1. Keep the 5 unit threshold for prions, but lower ones for the others. (1/2/3 nanites/eggs/gibbis, based on speed of disease progression and availability of the cure)
2. Remove dud poison bottles. Sulfonal for certain, maybe cyanide and sarin too because you can just make those. Curare is pretty shit, sodium thiopental too. And as much as I like getting amanitin, a bigger bottle of it would be great - quantity of amanitin to something like 200, since you need to use a lot of that on each person.
3. Make diseases contagious or harder to cure.
4. Change the way disease progression works. Remove the thresholds on nanites/eggs/gibbis, but disease progression is boosted for each life tick that the reagent exists in the body, unboosted natural disease progression is very slow. Extreme homeopathy will only start the disease, whereas the five unit dose will rapid-progress the disease to near-incurable speed.
5. Add more existing disease reagents to the lottery. I know R/Painbow fluid is a thing, and HIV. Pubbie tears, mucus, stringy gibbis, green mucus, salmonella, banana peel, necrovirus, liquid plasma, liquid spacetime, loose screws. Make the non-lethal ones permanent and uncurable because I actually love non-lethal traitoring. Turning the station into a hoard of berserker zombie clowns sounds like a great time.