Remove pathology until it's balanced.

[Mouse]

I'm almost tempted to suggest that the beneficial mutations symptom count as a negative one, unless a lot of mutations are removed. Skeleton makes you uncloneable unless they use genetics to turn you human (and the necroscan doesn't work iirc), metaneural haze and pseudonecrosis make it a lot more difficult for doctors to treat you, SMES will straight up kill you if you have a cyberheart or if your heart stops, the flashy skin mutation is just obnoxious as fuck, and I know there's a few others I'm forgetting.