Drop objects in Port-a-brig and Port-a-medbay and it's gone.

[mozi]

People can resist and remove the handcuffs while in the Port-a-brig.

Considering that people in a locked port-a-brig are just as stranded as someone who's bucklecuffed, if you leave someone in the Port-a-brig long enough for this to be a problem you are a bad Officer.

there was a funny round recently where sec managed to stuff a changeling into the portabrig and send it back to their office, but as everyone was going nuts trying to deal with all the neurotox victims and other madness that it just sat there the entire round, the changeling futilely using mimic voice over the radio to try and make someone let it out